5-(9-Fluorenylmethyloxycarbonylamino)-3-oxapentanoic acid

Name	5-(9-Fluorenylmethyloxycarbonylamino)-3-oxapentanoic acid
Synonyms	FMOC-O1PEN-OH Fmoc-5-amino-3-oxapentanoic acid [2-(FMOC-AMINO)ETHOXY]ACETIC ACID 5-(FMOC-AMINO)-3-OXAPENTANOIC ACID 5-(9-Fluorenylmethyloxycarbonylamino)-3-oxapentanoic acid 5-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3-OXAPENTANOIC ACID 5-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3-OXAPEMTANOIC ACID 5-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3-OXAPEMTANOIC ACID 5-(9-Fluorenylmethyloxycarbonyl-amino)-3-oxapentanoic acid, [2-(Fmoc-amino)ethoxy]acetic acid
CAS	260367-12-2
InChI	InChI=1/C19H19NO5/c21-18(22)12-24-10-9-20-19(23)25-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,17H,9-12H2,(H,20,23)(H,21,22)

Molecular Formula	C19H19NO5
Molar Mass	341.36
Density	1.287±0.06 g/cm3(Predicted)
Boling Point	602.6±40.0 °C(Predicted)
pKa	3.43±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.596
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

biological activity	Fmoc-NH-PEG1-CH2COOH is a degradable ADC linker used in antibody drug conjugate (ADC) synthesis. Fmoc-NH-PEG1-CH2COOH is also a PEG-based PROTAC linker and can be used in the synthesis of PROTAC.
Target	Cleavable aryl/ether PEGs
in vitro study	ADCs are combined of an antibody to which is attached an ADC cytoxin through an ADC linker. PROTACs contains two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intrinsic ubiquitin-proteasome system to selective grade target proteins.

Last Update：2024-04-09 21:11:58

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